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Strong Purifying Selection at Synonymous Sites in D. melanogaster

Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation. We use site frequency spectra from deep population sequencing data to show that, contrary to this expectation, 22% of f...

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Bibliografski detalji
Glavni autori: Lawrie, David S., Messer, Philipp W., Hershberg, Ruth, Petrov, Dmitri A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667748/
https://ncbi.nlm.nih.gov/pubmed/23737754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003527
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