Unexpected Opioid Activity Profiles of Analogs of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208

An alanine scan was performed on the novel kappa opioid receptor (KOR) peptide ligand CJ-15,208 to determine which residues contribute to the potent in vivo agonist activity observed for the parent peptide. These cyclic tetrapeptides were synthesized by a combination of solid phase peptide synthesis...

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Bibliografski detalji
Glavni autori: Aldrich, Jane V., Kulkarni, Santosh S., Senadheera, Sanjeewa N., Ross, Nicolette C., Reilley, Kate J., Eans, Shainnel O., Ganno, Michelle L., Murray, Thomas F., McLaughlin, Jay P.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667675/
https://ncbi.nlm.nih.gov/pubmed/21761566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100113
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