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The Influence of Active Site Location on Catalytic Activity in De Novo Designed Zinc Metalloenzymes
While metalloprotein design has now yielded a number of successful metal-bound and even catalytically active constructs, the question of where to put a metal site along a linear, repetitive sequence has not been thoroughly addressed. Often several possibilities in a given sequence may exist that wou...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3667658/ https://ncbi.nlm.nih.gov/pubmed/23516959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja401537t |
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