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The Catalytic Zinc Site and Mechanism of the Metalloenzyme PR-AMP Cyclohydrolase
The enzyme N(1)-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolase (PR-AMP cyclohydrolase) is a Zn(2+) metalloprotein encoded by the hisI gene. It catalyzes the third step of histidine biosynthesis (Scheme 1), an uncommon ring opening of a purine heterocycle for use in primary m...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427388/ https://ncbi.nlm.nih.gov/pubmed/22741521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300391m |
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