Pharmacological brake-release of mRNA translation enhances cognitive memory

Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique serine in eIF2α. This collection of signali...

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Main Authors: Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2013
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667625/
https://ncbi.nlm.nih.gov/pubmed/23741617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00498
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