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Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
We evaluate experimentally and computationally the membrane permeability of matched sets of peptidic small molecules bearing natural or bioisosteric unnatural amino acids. We find that the intentional introduction of hydrogen bond acceptor-donor pairs in such molecules can improve membrane permeabil...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325374/ https://ncbi.nlm.nih.gov/pubmed/22394492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201634q |
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