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Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.

Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...

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Bibliografiska uppgifter
Huvudupphovsmän: Folger, K R, Thomas, K, Capecchi, M R
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1985
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC366679/
https://ncbi.nlm.nih.gov/pubmed/3982420
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