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Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.

Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...

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Publicat a:Mol Cell Biol
Autors principals: Folger, K R, Thomas, K, Capecchi, M R
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1985
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC366679/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3982420/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.5.1.70-74.1985
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