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Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Receptor-mediated transcytosis across the blood–brain barrier (BBB) may be a useful way to transport therapeutics into the brain. Here we report that transferrin (Tf)-containing gold nanoparticles can reach the brain parenchyma from systemic administration in mice through a receptor-mediated transcy...

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Detalhes bibliográficos
Main Authors: Wiley, Devin T., Webster, Paul, Gale, Aaron, Davis, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666717/
https://ncbi.nlm.nih.gov/pubmed/23650374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307152110
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