Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been...

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Udgivet i:Theranostics
Main Authors: Johnsen, Kasper Bendix, Bak, Martin, Kempen, Paul Joseph, Melander, Fredrik, Burkhart, Annette, Thomsen, Maj Schneider, Nielsen, Morten Schallburg, Moos, Torben, Andresen, Thomas Lars
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010987/
https://ncbi.nlm.nih.gov/pubmed/29930740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.25228
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