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Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been...
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| Publicado en: | Theranostics |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Ivyspring International Publisher
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010987/ https://ncbi.nlm.nih.gov/pubmed/29930740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.25228 |
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