VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus

The first haematopoietic stem cells share a common origin with the dorsal aorta and derive from putative adult haemangioblasts in the dorsal lateral plate (DLP) mesoderm. Here we show that the transcription factor (TF) stem cell leukaemia (Scl/Tal1) is crucial for development of these adult haemangi...

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Hlavní autoři: Ciau-Uitz, Aldo, Pinheiro, Philip, Kirmizitas, Arif, Zuo, Jie, Patient, Roger
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2013
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666388/
https://ncbi.nlm.nih.gov/pubmed/23637333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.090829
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