Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage

Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulato...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kirmizitas, Arif, Meiklejohn, Stuart, Ciau-Uitz, Aldo, Stephenson, Rachel, Patient, Roger
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Sackler Colloquium on Gene Regulatory Networks and Network Models in Development and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468621/
https://ncbi.nlm.nih.gov/pubmed/28584091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610615114
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