Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage

Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulato...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Kirmizitas, Arif, Meiklejohn, Stuart, Ciau-Uitz, Aldo, Stephenson, Rachel, Patient, Roger
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Sackler Colloquium on Gene Regulatory Networks and Network Models in Development and Evolution
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468621/
https://ncbi.nlm.nih.gov/pubmed/28584091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610615114
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