Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

BACKGROUND: Multiple Myeloma (MM) is an incurable plasma cell malignancy residing within the bone marrow (BM). We aim to develop allogeneic Natural Killer (NK) cell immunotherapy for MM. As the BM contains hypoxic regions and the tumor environment can be immunosuppressive, we hypothesized that hypox...

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Main Authors: Sarkar, Subhashis, Germeraad, Wilfred T. V., Rouschop, Kasper M. A., Steeghs, Elisabeth M. P., van Gelder, Michel, Bos, Gerard M. J., Wieten, Lotte
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665801/
https://ncbi.nlm.nih.gov/pubmed/23724099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064835
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