Overcoming hypoxia-induced functional suppression of NK cells

BACKGROUND: Natural killer (NK) cells are immune cells capable of killing virally infected cells and tumor cells without the need for antigen stimulation. Tumors, however, can create a suppressive microenvironment that decreases NK function. A feature of many tumors is hypoxia (low oxygen perfusion)...

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Dettagli Bibliografici
Pubblicato in:J Immunother Cancer
Autori principali: Solocinski, Kristen, Padget, Michelle R, Fabian, Kellsye P, Wolfson, Benjamin, Cecchi, Fabiola, Hembrough, Todd, Benz, Stephen C, Rabizadeh, Shahrooz, Soon-Shiong, Patrick, Schlom, Jeffrey, Hodge, James W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Immune Cell Therapies and Immune Cell Engineering
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213912/
https://ncbi.nlm.nih.gov/pubmed/32345623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000246
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