Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells

BACKGROUND: As heterogeneous tumors develop in the face of intact immunity, tumor cells harboring genomic or expression defects that favor evasion from T-cell detection or elimination are selected. For patients with such tumors, T cell-based immunotherapy alone infrequently results in durable tumor...

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Foilsithe in:J Immunother Cancer
Main Authors: Lee, Maxwell Y, Robbins, Yvette, Sievers, Cem, Friedman, Jay, Abdul Sater, Houssein, Clavijo, Paul E, Judd, Nancy, Tsong, Edward, Silvin, Chris, Soon-Shiong, Patrick, Padget, Michelle R, Schlom, Jeffrey, Hodge, James, Hinrichs, Christian, Allen, Clint
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Publishing Group 2021
Ábhair:
Basic Tumor Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986659/
https://ncbi.nlm.nih.gov/pubmed/33741731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002128
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