Overexpression of p16(INK4a) in Urothelial Carcinoma In Situ Is a Marker for MAPK-Mediated Epithelial-Mesenchymal Transition but Is Not Related to Human Papillomavirus Infection

BACKGROUND: The role of human papillomavirus (HPV) in bladder carcinogenesis remains controversial. Overexpression of p16(INK4a), a surrogate marker for infection with oncogenic HPV in other tumours, has been described for urothelial carcinoma in situ (UCIS). Our goal was therefore to evaluate wheth...

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Autori principali: Steinestel, Julie, Cronauer, Marcus V., Müller, Johannes, Al Ghazal, Andreas, Skowronek, Peter, Arndt, Annette, Kraft, Klaus, Schrader, Mark, Schrader, Andres J., Steinestel, Konrad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665800/
https://ncbi.nlm.nih.gov/pubmed/23724131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065189
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