Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling

Mutations in inverted formin 2 INF2 are a common cause of familial FSGS. INF2 interacts with diaphanous-related formins (mDia) and antagonizes mDia-mediated actin polymerization in response to active Rho signaling, suggesting that dysregulation of these pathways may mediate the development of INF2-r...

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Detaylı Bibliyografya
Asıl Yazarlar: Sun, Hua, Schlondorff, Johannes, Higgs, Henry N., Pollak, Martin R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2013
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665394/
https://ncbi.nlm.nih.gov/pubmed/23620398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012080834
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