DNA Replication Checkpoint Signaling Depends on a Rad53–Dbf4 N-Terminal Interaction in Saccharomyces cerevisiae

Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) are essential to initiate DNA replication at individual origins. During replication stress, the S-phase checkpoint inhibits the DDK- and CDK-dependent activation of late replication origins. Rad53 kinase is a central effector of the repli...

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Bibliografiske detaljer
Main Authors: Chen, Ying-Chou, Kenworthy, Jessica, Gabrielse, Carrie, Hänni, Christine, Zegerman, Philip, Weinreich, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2013
Fag:
Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664849/
https://ncbi.nlm.nih.gov/pubmed/23564203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.149740
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