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Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation
The initiation of eukaryotic DNA replication is regulated by three protein kinase classes: cyclin dependent kinases (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases1. CDK phosphorylation of two key initiation factors, Sld2 and Sld3, promotes essential interactions with Dpb112...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948544/ https://ncbi.nlm.nih.gov/pubmed/20835227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09373 |
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