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53BP1 regulates DSB repair using Rif1 to control 5’ end resection
The choice between double-strand break (DSB) repair by either homology-directed repair (HDR) or non-homologous end-joining (NHEJ) is tightly regulated. Defects in this regulation can induce genome instability and cancer. 53BP1 is critical for the control of DSB repair, promoting NHEJ and inhibiting...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664841/ https://ncbi.nlm.nih.gov/pubmed/23306437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231573 |
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