LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma

The histone deacetylase inhibitor belinostat is being evaluated clinically as a single agent in the treatment of Peripheral T-cell lymphomas and in combination with other anticancer agents to treat a wide range of human cancers including acute leukemias and solid tumors. To determine the pharmacokin...

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Detalhes bibliográficos
Main Authors: Kiesel, Brian F., Parise, Robert A., Tjørnelund, Jette, Christensen, Mette K., Loza, Einars, Tawbi, Hussein, Chu, Edward, Kummar, Shivaani, Beumer, Jan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663884/
https://ncbi.nlm.nih.gov/pubmed/23644904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2013.03.025
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