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Dihydroceramide accumulation and reactive oxygen species are distinct and non essential events in 4-HPR mediated leukemia cell death
4-(hydroxyphenyl)retinamide (4-HPR) is a synthetic retinoid with strong apoptotic effect towards different cancer cell lines in vitro, and it is currently tested in clinical trials. Increases of Reactive Oxygen Species (ROS) and modulation of endogenous sphingolipid levels are well-described events...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663831/ https://ncbi.nlm.nih.gov/pubmed/22428532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/o2012-001 |
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