Interferon Regulatory Factor 8-Deficiency Determines Massive Neutrophil Recruitment but T Cell Defect in Fast Growing Granulomas during Tuberculosis

Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS). Interferon regulatory factor-8 (IRF-8) plays an important role in host defense against Mtb, al...

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Detalhes bibliográficos
Main Authors: Rocca, Stefano, Schiavoni, Giovanna, Sali, Michela, Anfossi, Antonio Giovanni, Abalsamo, Laura, Palucci, Ivana, Mattei, Fabrizio, Sanchez, Massimo, Giagu, Anna, Antuofermo, Elisabetta, Fadda, Giovanni, Belardelli, Filippo, Delogu, Giovanni, Gabriele, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663794/
https://ncbi.nlm.nih.gov/pubmed/23717393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062751
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