Interferon Regulatory Factor 8-Deficiency Determines Massive Neutrophil Recruitment but T Cell Defect in Fast Growing Granulomas during Tuberculosis

Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS). Interferon regulatory factor-8 (IRF-8) plays an important role in host defense against Mtb, al...

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Bibliographic Details
Main Authors: Rocca, Stefano, Schiavoni, Giovanna, Sali, Michela, Anfossi, Antonio Giovanni, Abalsamo, Laura, Palucci, Ivana, Mattei, Fabrizio, Sanchez, Massimo, Giagu, Anna, Antuofermo, Elisabetta, Fadda, Giovanni, Belardelli, Filippo, Delogu, Giovanni, Gabriele, Lucia
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663794/
https://ncbi.nlm.nih.gov/pubmed/23717393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062751
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