Activation of the Heat Shock Response Attenuates the IL-1β-mediated Inhibition of the Amiloride-Sensitive Alveolar Epithelial Ion Transport

Acute lung injury (ALI) is a clinical syndrome characterized by hypoxia which is caused by the breakdown of the alveolar capillary barrier. IL-1β a cytokine released within the airspace in ALI, down-regulates αENaC transcription and protein expression via p38 MAP kinase-dependent signaling. While in...

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Main Authors: Howard, Marybeth, Roux, Jérémie, Iles, Karen E., Miyazawa, Byron, Christiaans, Sarah, Anjum, Naseem, Dickinson, Dale A., Goolaerts, Arnaud, Matthay, Michael A., Pittet, Jean Francois
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663580/
https://ncbi.nlm.nih.gov/pubmed/23324889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e31827e8ea3
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