IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism

Patients with acute lung injury (ALI) who retain maximal alveolar fluid clearance (AFC) have better clinical outcomes. Experimental and small clinical studies have shown that β(2)-adrenergic receptor (β(2)AR) agonists enhance AFC via a cAMP-dependent mechanism. However, two multicenter phase 3 clini...

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Detalhes bibliográficos
Main Authors: Roux, Jérémie, McNicholas, Carmel M., Carles, Michel, Goolaerts, Arnaud, Houseman, Benjamin T., Dickinson, Dale A., Iles, Karen E., Ware, Lorraine B., Matthay, Michael A., Pittet, Jean-François
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574281/
https://ncbi.nlm.nih.gov/pubmed/23221335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219295
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