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The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence

The Mycobacterium tuberculosis gene Rv3232c/MT3329 (ppk2) encodes a class II polyphosphate kinase, which hydrolyzes inorganic polyphosphate (poly P) to synthesize GTP. We assessed the role of ppk2 in M. tuberculosis poly P regulation, antibiotic tolerance, and virulence. A ppk2-deficient mutant (ppk...

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Bibliografski detalji
Glavni autori: Chuang, Yu-Min, Belchis, Deborah A., Karakousis, Petros C.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663568/
https://ncbi.nlm.nih.gov/pubmed/23695835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00039-13
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