Differential Role for Transcription Factor Oct4 Nucleocytoplasmic Dynamics in Somatic Cell Reprogramming and Self-renewal of Embryonic Stem Cells

Oct4 is a member of the POU family of transcription factors and plays a critical role in both maintenance of the undifferentiated state of embryonic stem (ES) cells and in the reprogramming of somatic cells to induced pluripotent stem cells. Oct4 is imported into the nucleus where it functions as a...

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Autores principales: Oka, Masahiro, Moriyama, Tetsuji, Asally, Munehiro, Kawakami, Koichi, Yoneda, Yoshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663529/
https://ncbi.nlm.nih.gov/pubmed/23580657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448837
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