E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming

We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully...

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Detalhes bibliográficos
Main Authors: Redmer, Torben, Diecke, Sebastian, Grigoryan, Tamara, Quiroga-Negreira, Angel, Birchmeier, Walter, Besser, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128971/
https://ncbi.nlm.nih.gov/pubmed/21617704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.88
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