A Novel Transcription Mechanism Activated by Ethanol: INDUCTION OF Slc7a11 GENE EXPRESSION VIA INHIBITION OF THE DNA-BINDING ACTIVITY OF TRANSCRIPTIONAL REPRESSOR OCTAMER-BINDING TRANSCRIPTION FACTOR 1 (OCT-1)

Solute carrier family 7, member 11 (Slc7a11) is a plasma membrane cystine/glutamate exchanger that provides intracellular cystine to produce glutathione, a major cellular antioxidant. Oxidative and endoplasmic reticulum stresses up-regulate Slc7a11 expression by activation of nuclear factor erythroi...

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Detalhes bibliográficos
Main Authors: Lin, Xinghua, Yang, Hong, Zhang, Hongfeng, Zhou, LiChun, Guo, ZhongMao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663505/
https://ncbi.nlm.nih.gov/pubmed/23592778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466565
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