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A Novel Transcription Mechanism Activated by Ethanol: INDUCTION OF Slc7a11 GENE EXPRESSION VIA INHIBITION OF THE DNA-BINDING ACTIVITY OF TRANSCRIPTIONAL REPRESSOR OCTAMER-BINDING TRANSCRIPTION FACTOR 1 (OCT-1)
Solute carrier family 7, member 11 (Slc7a11) is a plasma membrane cystine/glutamate exchanger that provides intracellular cystine to produce glutathione, a major cellular antioxidant. Oxidative and endoplasmic reticulum stresses up-regulate Slc7a11 expression by activation of nuclear factor erythroi...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663505/ https://ncbi.nlm.nih.gov/pubmed/23592778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466565 |
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