Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling

Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) is coordinated by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The soluble IL-6R is mainly generated by ADAM10- and ADAM17-mediated ectodomain shedding. Little i...

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Bibliografiske detaljer
Main Authors: Baran, Paul, Nitz, Rebecca, Grötzinger, Joachim, Scheller, Jürgen, Garbers, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663500/
https://ncbi.nlm.nih.gov/pubmed/23564454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466169
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