The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling

Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively. Whereas inflammation triggers IL-6 expression, eventually risi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Baran, Paul, Hansen, Selina, Waetzig, Georg H., Akbarzadeh, Mohammad, Lamertz, Larissa, Huber, Heinrich J., Ahmadian, M. Reza, Moll, Jens M., Scheller, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936821/
https://ncbi.nlm.nih.gov/pubmed/29559558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001163
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