Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca(2+) elevation

Connexin mimetic peptides (CxMPs), such as Gap26 and Gap27, are known as inhibitors of gap junction channels but evidence is accruing that these peptides also inhibit unapposed/non-junctional hemichannels (HCs) residing in the plasma membrane. We used voltage clamp studies to investigate the effect...

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Detalhes bibliográficos
Main Authors: Wang, Nan, De Bock, Marijke, Antoons, Gudrun, Gadicherla, Ashish K., Bol, Mélissa, Decrock, Elke, Evans, William Howard, Sipido, Karin R., Bukauskas, Feliksas F., Leybaert, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662472/
https://ncbi.nlm.nih.gov/pubmed/23095853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-012-0304-2
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