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Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic β-cells
Functional β-cell mass deficiency in diabetes results from imbalanced β-cell death and replication, and decreased PAK1 protein levels in human islets from donors with type 2 diabetes implicates a possible role for PAK1 in maintaining β-cell mass. Here, we aim to address the linkage between PAK1 and...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3662379/ https://ncbi.nlm.nih.gov/pubmed/23514967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.24029 |
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