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Copper-Catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)-Naseseazines A and B

A copper-catalyzed arylation of tryptophan derivatives is reported. The reaction proceeds with high site- and diastereoselectivity to provide aryl pyrroloindoline products in one step from simple starting materials. The utility of this transformation is highlighted in the five step syntheses of the...

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Autors principals: Kieffer, Madeleine E., Chuang, Kangway V., Reisman, Sarah E.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662218/
https://ncbi.nlm.nih.gov/pubmed/23540731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4023557
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