An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting...

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Detalhes bibliográficos
Main Authors: Li, Lihua, Wang, Yan, Chen, Jun, Cheng, Bi, Hu, Jiehua, Zhou, Yuehua, Gao, Xin, Gao, Liucun, Mei, Xifan, Sun, Meiyan, Zhang, Zhuomei, Song, Haifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662114/
https://ncbi.nlm.nih.gov/pubmed/23737831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/423129
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