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An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting...

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Bibliografiske detaljer
Main Authors: Li, Lihua, Wang, Yan, Chen, Jun, Cheng, Bi, Hu, Jiehua, Zhou, Yuehua, Gao, Xin, Gao, Liucun, Mei, Xifan, Sun, Meiyan, Zhang, Zhuomei, Song, Haifeng
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662114/
https://ncbi.nlm.nih.gov/pubmed/23737831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/423129
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