Dichloroacetate Reverses the Hypoxic Adaptation to Bevacizumab and Enhances its Antitumor Effects in Mouse Xenografts

Inhibition of vascular endothelial growth factor (VEGF) increases response rates to chemotherapy and progression-free survival in glioblastoma. However, resistance invariably occurs, prompting the urgent need for identification of synergizing agents. One possible strategy is to understand tumor adap...

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Hlavní autoři: Kumar, Krishnan, Wigfield, Simon, Gee, Harriet E., Devlin, Cecilia M., Singleton, Dean, Li, Ji-Liang, Buffa, Francesca, Huffman, Melanie, Sinn, Anthony L., Silver, Jayne, Turley, Helen, Leek, Russell, Harris, Adrian L, Ivan, Mircea
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661713/
https://ncbi.nlm.nih.gov/pubmed/23361368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-0996-2
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