Prostaglandin E(2) Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion

BTBR mice develop severe diabetes in response to genetically induced obesity due to a failure of the β-cells to compensate for peripheral insulin resistance. In analyzing BTBR islet gene expression patterns, we observed that Pgter3, the gene for the prostaglandin E receptor 3 (EP3), was upregulated...

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Bibliografiske detaljer
Main Authors: Kimple, Michelle E., Keller, Mark P., Rabaglia, Mary R., Pasker, Renee L., Neuman, Joshua C., Truchan, Nathan A., Brar, Harpreet K., Attie, Alan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661627/
https://ncbi.nlm.nih.gov/pubmed/23349487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0769
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