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Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress

Endoplasmic reticulum (ER) stress is suggested to cause hepatic insulin resistance by increasing de novo lipogenesis (DNL) and directly interfering with insulin signaling through the activation of the c-Jun N-terminal kinase (JNK) and IκB kinase (IKK) pathway. The current study interrogated these tw...

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Bibliografiske detaljer
Main Authors: Chan, Stanley M.H., Sun, Ruo-Qiong, Zeng, Xiao-Yi, Choong, Zi-Heng, Wang, Hao, Watt, Matthew J., Ye, Ji-Ming
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661626/
https://ncbi.nlm.nih.gov/pubmed/23349482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1397
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