Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats

Our objective was to determine if the insulin-sensitizing drug pioglitazone acutely reduces insulin secretion and causes metabolic deceleration in vivo independently of change in insulin sensitivity. We assessed glucose homeostasis by hyperinsulinemic-euglycemic and hyperglycemic clamp studies and e...

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Главные авторы: Lamontagne, Julien, Jalbert-Arsenault, Élise, Pepin, Émilie, Peyot, Marie-Line, Ruderman, Neil B., Nolan, Christopher J., Joly, Erik, Madiraju, S.R. Murthy, Poitout, Vincent, Prentki, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2013
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661607/
https://ncbi.nlm.nih.gov/pubmed/23378607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0428
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