A Functional Yeast Survival Screen of Tumor-Derived cDNA Libraries Designed to Identify Anti-Apoptotic Mammalian Oncogenes

Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors. The screening of three different cDNA libraries prepared from m...

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Main Authors: Eißmann, Moritz, Schwamb, Bettina, Melzer, Inga Maria, Moser, Julia, Siele, Dagmar, Köhl, Ulrike, Rieker, Ralf Joachim, Wachter, David Lukas, Agaimy, Abbas, Herpel, Esther, Baumgarten, Peter, Mittelbronn, Michel, Rakel, Stefanie, Kögel, Donat, Böhm, Stefanie, Gutschner, Tony, Diederichs, Sven, Zörnig, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661464/
https://ncbi.nlm.nih.gov/pubmed/23717670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064873
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