Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

OBJECTIVES: Variants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effe...

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Detalhes bibliográficos
Main Authors: Mayne, Janice, Ooi, Teik Chye, Raymond, Angela, Cousins, Marion, Bernier, Lise, Dewpura, Thilina, Sirois, Francine, Mbikay, Majambu, Davignon, Jean, Chrétien, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661383/
https://ncbi.nlm.nih.gov/pubmed/23663650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-12-70
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