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Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes

It was recently shown that the expansion of CD4+ T cells during a primary immune reaction to a peptide from cytochrome c decreases approximately 0.5 log for every log increase in the number of cognate precursor cells, and that this remains valid over more than four orders of magnitude [Quiel, et al....

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Hlavní autoři: De Boer, Rob J., Perelson, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661195/
https://ncbi.nlm.nih.gov/pubmed/23606541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203569
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