Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing

BACKGROUND: Mutations involving isocitrate dehydrogenase 1 (IDH 1) occur in a high proportion of diffuse gliomas, with implications on diagnosis and prognosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine with histidine (R132H). Rarer ones include R132C, R132S, R132G, R132L,...

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Main Authors:	Agarwal, Shipra, Sharma, Mehar Chand, Jha, Prerana, Pathak, Pankaj, Suri, Vaishali, Sarkar, Chitra, Chosdol, Kunzang, Suri, Ashish, Kale, Shashank Sharad, Mahapatra, Ashok Kumar, Jha, Pankaj
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2013
Fag:	Basic and Translational Investigations
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3661098/ https://ncbi.nlm.nih.gov/pubmed/23486690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not015
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Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing

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