Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing

BACKGROUND: Mutations involving isocitrate dehydrogenase 1 (IDH 1) occur in a high proportion of diffuse gliomas, with implications on diagnosis and prognosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine with histidine (R132H). Rarer ones include R132C, R132S, R132G, R132L,...

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Detalhes bibliográficos
Main Authors: Agarwal, Shipra, Sharma, Mehar Chand, Jha, Prerana, Pathak, Pankaj, Suri, Vaishali, Sarkar, Chitra, Chosdol, Kunzang, Suri, Ashish, Kale, Shashank Sharad, Mahapatra, Ashok Kumar, Jha, Pankaj
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661098/
https://ncbi.nlm.nih.gov/pubmed/23486690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not015
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