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Bayesian hierarchical model of protein-binding microarray k-mer data reduces noise and identifies transcription factor subclasses and preferred k-mers

Motivation: Sequence-specific transcription factors (TFs) regulate the expression of their target genes through interactions with specific DNA-binding sites in the genome. Data on TF-DNA binding specificities are essential for understanding how regulatory specificity is achieved. Results: Numerous s...

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Main Authors: Jiang, Bo, Liu, Jun S., Bulyk, Martha L.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661050/
https://ncbi.nlm.nih.gov/pubmed/23559638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt152
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