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Hierarchical Clustering of DNA k-mer Counts in RNAseq Fastq Files Identifies Sample Heterogeneities

We apply hierarchical clustering (HC) of DNA k-mer counts on multiple Fastq files. The tree structures produced by HC may reflect experimental groups and thereby indicate experimental effects, but clustering of preparation groups indicates the presence of batch effects. Hence, HC of DNA k-mer counts...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kaisers , Wolfgang, Schwender, Holger, Schaal , Heiner
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274891/
https://ncbi.nlm.nih.gov/pubmed/30469355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113687
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