An NMDA Receptor Gating Mechanism Developed from MD Simulations Reveals Molecular Details Underlying Subunit-Specific Contributions

N-methyl-D-aspartate (NMDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in learning and memory. Here, using targeted molecular dynamics simulations, we developed an atomistic model for the gating of the GluN1/GluN2A NMDA receptor. Upon agonist binding,...

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Bibliographic Details
Main Authors: Dai, Jian, Zhou, Huan-Xiang
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2013
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660646/
https://ncbi.nlm.nih.gov/pubmed/23708357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.013
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